Star Trek, also known as "TOS" or The Original Series, debuted in the United States on NBC on September 8, 1966

Star Trek: The Animated Series was produced by Filmation and ran for two seasons from 1973 to 1974. Most of the original cast performed the voices of their characters from The Original Series, and many of the original series' writers, such as D. C. Fontana, David Gerrold and Paul Schneider, wrote for the series.

Star Trek: The Next Generation, also known as "TNG", is set approximately 70 years after The Original Series. It features a new starship, the Enterprise-D, and a new crew led by Captain Jean-Luc Picard (Patrick Stewart) and Commander William Riker (Jonathan Frakes). The series introduced alien races new to the Federation as crew members, including Deanna Troi, a half-Betazoid counselor played by Marina Sirtis, and Worf as the first Klingon officer in Starfleet, played by Michael Dorn.

Star Trek: Voyager was produced for seven seasons, airing from January 16, 1995 to May 23, 2001. It features Kate Mulgrew as Captain Kathryn Janeway, the first female commanding officer in a leading role of a Star Trek series. Voyager takes place at about the same time as Deep Space Nine

Star Trek: Deep Space Nine, also known as "DS9", is set during the last years and the immediate post-years of The Next Generation and was in production for seven seasons, debuting the week of January 3, 1993. It is the only Star Trek series to take place primarily on a space station rather than aboard a starship. It is set on the Cardassian-built space station Deep Space Nine, located near the planet Bajor and a uniquely stable wormhole that provides immediate access to the distant Gamma Quadrant.

Star Trek: Enterprise, originally titled Enterprise, produced for an abbreviated four seasons airing from September 26, 2001 to May 13, 2005, is a prequel to the other Star Trek series, taking place in the 2150s, some 90 years after Zefram Cochrane developed the first warp-capable starship from a ballistic missile and about a decade before the founding of the Federation. The series shows how the first extraterrestrial contact with the Vulcans and subsequent guidance led to Earth's first warp-five capable starship, the Enterprise, commanded by Captain Jonathan Archer (Scott Bakula)